Linking biology with cognition in the global brain
I will first discuss a biologically-based model of “cognitive-type” microcircuits, with the prefrontal cortex as an example, that are capable of working memory and decision-making. The model is characterized by slow (NMDA-receptor dependent) recurrent attractor dynamics, and has led to the proposal of a disinhibitory circuit motif implemented by three subtypes of (PV+, CB/SOM+ and CR/VIP+) inhibitory neurons. This line of research also begins to impact on clinical research in Psychiatry.