Reinforcement learning biases in general and clinical population

Abstract: Reinforcement learning (RL) encompasses different applications in machine learning, psychology, and neuroscience, emerging from the combination of animal learning theories and mathematical algorithms. It is a great tool to study decision-making and explore inter-groups differences. In this work, we use RL modeling to investigate decision making biases that take place at different stages of decision-making and that are expressed in various ways depending on the population.

A computational and neural model for mood dynamics

The happiness of individuals is an important metric for societies, but we know relatively little about how daily life events are aggregated into subjective feelings. We show that happiness depends on the history of expectations and prediction errors resulting from those expectations, a result we have now replicated in thousands of individuals using smartphone-based data collection (https://happinessquest.app). Using fMRI, we show how happiness relates to neural activity and to the neuromodulator dopamine.

Trial matching: capturing variability with data-constrained spiking neural networks

Simultaneous behavioral and electrophysiological recordings call for new methods to reveal the interactions between neural activity and behavior. One main challenge is to create an interpretable model of the co-variability of spiking activity and behavior across trials. In this talk, we will present our model of a mouse cortical sensory-motor pathway in a tactile detection task reported by licking.

Dopamine and the circuit computations underlying motivation

afficheMotivation–the energizing of behavior in pursuit of a goal–is central to daily life. Disruptions in motivation underpin multiple neuropsychiatric disorders, from abnormally low motivation in anhedonia to abnormally high motivation in addiction. Although dopamine (DA) release has long been implicated in motivated behavior, the mechanisms of that link remain unclear.

Neural representations of learning and behavior

A fundamental question in neuroscience is to understand how coordinated neural activity and structured circuitry in the brain are responsible for generating behavior. Decades of experimental and theoretical work have demonstrated that correlated neural activity has a strong impact on population coding by reshaping neural representations of external stimuli. More recently, large-scale recordings have provided insight as to the dynamic mechanisms by which neural populations perform computations, but the link to their circuitry remains unclear.

Ethnic-racial discrimination influences on neural representation of threat and safety learning in children: A community-engaged approach

Ethnic-racial discrimination is a salient reality and powerful threat for minoritized youth which poses a serious community health concern as it is associated with deleterious mental health outcomes such as anxiety. During middle childhood, when important regulatory brain networks are undergoing substantial change, exposure to discrimination may affect brain development and exacerbate behaviors that maintain and escalate anxiety symptoms.